PF-06700841 TOSYLATE SALT

Code: PZ0345-5MG D2-231

Application

PF-06700841 tosylate salt has been used as an inhibitor of Janus kinase1 (JAK1) to study its therapeutic effect on the adjuvant induced arthritis (AIA) rat model....


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€118.01 5MG
€145.15 inc. VAT
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Application

PF-06700841 tosylate salt has been used as an inhibitor of Janus kinase1 (JAK1) to study its therapeutic effect on the adjuvant induced arthritis (AIA) rat model. It has also been used as an inhibitor of interferon-α/β receptor alpha chain (IFNAR1) signaling adaptor tyrosine kinase (2TYK2) in mice.

Biochem/physiol Actions

PF-06700841 prevents IL-23 (interleukin 23) signaling through TYK2 (Tyrosine-protein kinase 2)/JAK1 (Janus kinase 1) inhibition.

PF-06700841 is an inhibitor of JAK1 and TYK2 kinases. PF-06700841 has been investigated for the treatment of psoriasis and lupus.

Legal Information

Pfizer is a registered trademark of Pfizer, Inc.

Packaging

5 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
manufacturer/tradenamePfizer®
originatorPfizer
Quality Level100
SMILES stringFC1(F)C[C@H]1C(N2[C@H]3CN(C4=CC=NC(NC5=CN(C)N=C5)=N4)C[C@@H]2CC3)=O.CC6=CC=C(S(=O)(O)=O)C=C6
solubilityDMSO: 5 mg/mL, clear (warmed)
storage temp.room temp
Cas Number1883299-62-4
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